Hi ~beefox! Your post reminded me to
Ferran Sunyer i Balaguer (his biography in Catalan; it is more detailed than the English version)TLDR; He was very disabled and he lived in a town. He couldn't go to university and learned mathematics in the summer, from the engineering books of his cousin!
He was a well recognized mathematician with many important publications (he dictated them to his mother and sister), but in Spain, legally, he wasn't a researcher. He had to pass the exams to get the bachelor's degree in mathematics (I think it took him a year) and did a PhD. When he finally obtained a researcher position, died 18 days later.
There is a documentary that I haven't seen yet! Let me know if you want to know something else about him :)